Reformation in continental Europe and England and its...

Reformation is the religious revolution that took place in Western Europe in the 16th century. It arose from objections to doctrines and practices in the medieval church, loss of papal authority and credibility as well as other societal, political and economical issues of the time. This revolution had a major impact on Europe and it gave way to short term and long-term consequences, which still can be seen today. There were many causes of Reformation, some go as far back as the fourteenth century. One of the main ones was that the papal authority and credibility were damaged. This was done through, Avignon papacy, - a time where the headquarters of the Holy See had to be moved from Rome to Avignon, it brought uncertainty to the people,†¦show more content†¦It raised the level of education and brought about new scientific discoveries. Renaissance emphasized biblical languages, and allowed for critical analysis of the Bible. This led to different doctrinal interpretations such as that of Martin Luther in Germany, who was convinced that salvation came through faith in Jesus and not the sacraments of Church and John Calvin in Switzerland, who believed God has decided the destiny of a person and nothing could change this. The invention of printing by Johann Gutenberg provided a powerful instrument for the spread of these learning and Reformation ideas e.g John Calvinà ¢Ã¢â€š ¬Ã¢â€ž ¢s à ¢Ã¢â€š ¬Ã…“Institutes of the Christian religionà ¢Ã¢â€š ¬?. This sped up the Reformation because it allowed widespread broadcasting of criticism of the Church around Europe. While these were the main causes of Reformation in continental Europe, in England, King Henry VIII initiated the Reformation. Henry VIII wanted to divorce his first wife, Catherine of Aragon, after she had failed to produce a male heir to the throne. However, a divorce was not a simple issue. Henry VIII was a Roman Catholic and the Roman Catholic faith believed in marriage for life. It did not recognise, let alone support, divorce. He also wanted to prevent the interference of foreign powers in the national and international affairs of the country.Show MoreRelatedReformation in Continental Europe and England and Its Consequences1611 Words   |  7 PagesReformation is the religious revolution that took place in Western Europe in the 16th century. It arose from objections to doctrines and practices in the medieval church, loss of papal authority and credibility as well as other societal, political and economical issues of the time. This revolution had a major impact on Europe and it gave way to short term and long-term consequences, which still can be seen today. There were many causes of Reformation, some go as far back as the fourteenth centuryRead MoreThe Beginning Of The Reformation1476 Words   |  6 PagesTask 1: Describe the beginning of the Reformation in Germany (including who, when, and where). â€Å"The Protestant Reformation was the 16th-century religious, political, intellectual and cultural uprising that splintered Catholic Europe, setting in place the structures and beliefs that would define the continent in the modern era. In northern and central Europe, reformers like Martin Luther and Henry VIII challenged papal authority and questioned the Catholic Church’s ability to define ChristianRead MoreThe Kingdom of the Netherlands1756 Words   |  8 Pagesof dikes, wooden windmills, and fields of colorful tulips. A land of diverse and varied history, the Netherlands has overcome intriguing struggles in many centuries, impacting the world despite its diminutive size. Among the smaller countries in Europe, the Netherlands’ ranks thirty-first out of forty-five countries. The country has many valuable assets, such as the famed Ruhr industrial zone lusted after by the ambitious Germans in World War II. It would be an understatement to say that theRead MoreReading Key3881 Words   |  16 Pagesthe floor of the Great Basin. Salt Lake lost its outlet and evaporation caused it to become saline. Appalachian Mountains: Formed before continental separation. 350 million yrs. Ago. Tidewater Region: Caused by many river valleys. Slope upward to the Appalachians. Rocky Mountains: 135-25 million yrs. ago after continental separation. Great Lakes: weight of the ice caused depressions in the Canadian Shield. This scoured away the topsoil Missouri Mississippi-OhioRead MoreThe French Revolution, the Industrial Revolution and the American Revolution1831 Words   |  8 Pagesthe oversized books in English. Introduction The definition of a Revolution according to the National Encyclopedia is a fundamental change, often over a short period of time. Politically the word was first used during the Glorious Revolution of England in 1688. However, there are three other major revolutions during the time period 1688 Ââ€" 1789 that this essay will shed light on. The American Revolution, the French Revolution and the Industrial Revolution are all important revolutions of its timeRead MoreThe Features Of Early Childhood Education1920 Words   |  8 Pagesperspectives on early childhood education in England and some other nations like Italy, determine the relationship existing in the history of early childhood provision in the UK and its present frame and state clearly the role of practitioner in planning and putting on a broad and balanced, child-centred curriculum within the indoor, outdoor environment and outside the early childhood context. Early childhood care and education for young children began to develop in England in the late 18th century and wasRead MoreNineteenth Century Americ A Bleak Portrayal Of The Sociopolitical Scene3092 Words   |  13 PagesPuritan New England experienced one of the most peculiarly memorable historical events of all time. The Salem Witchcraft trials of 1692 remain prominently embodied in the long and colorful history of New England, stretching back into the pre-colonial period. In the grand scheme of things, the Salem trials were the results of a long struggle between the mainstream catholic faith and the early Protestants. It is worth to mention from this outset that Catholicism had spread all over Europe by the eleventhRead MoreBritish National Identity8214 Words   |  33 PagesBRITISH NATIONAL IDENTITY What is national identity in postmodern Great Britain? 21st century Europe. Postmodernism. European Union. Capitalism. Fragmentation. In search of a new identity. Divided and together facing the rest of the world. History turns to be an invaluable source for the researchers to tackle properly the term. But history was written by the conquerors. The truth is probably in-between. In The importance of not being English, David McDowall states that national identity nowadaysRead MoreSociology and Other Sciences7090 Words   |  29 Pagesearlier researchers, notably Adolf Wagner and Henry Morselli, who were much more careful in generalizing from their own data. Second, later researchers found that the Protestant-Catholic differences in suicide seemed to be limited to German-speaking Europe and thus may always have been the spurious reflection of other factors. Despite its limitations, Durkheims work on suicide has influenced proponents of control theory, and is often mentioned as a classic sociological study. Durkheims study of suicideRead MoreExploring Corporate Strategy - Case164366 Words   |  658 Pages(A) – long term planning of a successful dot.com. Jordan – the challenge of building capabilities for success in Formula 1. Shefï ¬ eld Theatres – strategy formulation for a wide audience of public and commercial stakeholders. Fisons – disastrous consequences of stakeholder management. Iona – Mission-driven strategy and stakeholder management. HomeCo – wrestling with governance and strategy in the boardroom; a role play. BMW – driving organic growth through market development in the automotive industry

The Tragic Heroes Of Sophocles Oedipus The King And...

Rough Draft Ignorance is one of the most hidden but controlling characteristics one may have. It carves the path for many plays and stories and is usually not recognized until a situation is too late to fix. This is represented in the two plays Oedipus the King and Antigone by Sophocles. Oedipus and Creon, the two the tragic heroes, have ignorance built up inside of them, though both are different. They then both then have realisation of their blindness by self-love, either by themselves or others. It is only two late when they see reality because they have already lost something dear to them and later grieve, only blaming themselves. Though both stories are formated the same, both show different lessons and circumstances. In both Oedipus the King and Antigone, the tragic heroes are masked in ignorance which after a tragic downfall, is only recognized after it’s too late and an item dear to them is gone. In the story of Oedipus the King, the tragic hero, Oedipus, is masked in ignorance from the reality of his ruling of Thebes. Because of his ignorance, he is fast to make assumptions and tends to stick with them. He makes the speculation that Creon is manipulatively trying to kick Oedipus out of his position as king. â€Å"Must Creon. so long my friend, my most trusted friend, Stalk me by stealth, and study to dispossess of me, Of this power this city has given me- freely given - This pedlar of fraudulent magical tricks, with eyes Wide open for profit, but blind in prophecy?†Show MoreRelatedAnalysis Of Antigone By Sophocles1074 Words   |  5 Pages1 Gabriel Smith Professor Christopher Foster English 1302 01 March 2016 Essay 2: Antigone A hero is a person who shows courage or noble qualities in the face of danger. There are many different types of heroes in literature and media such as superheroes saving the world, or an everyday fireman saving a kitten from a tree. Deriving from Greek literature, tragic heroes are common among early literature. Tragic heroes are defined by Aristotle by the following requirements, they must come from royaltyRead MoreAntigone by Sophocles1059 Words   |  5 Pages In the book Antigone, Creon and Antigone can be considered as the tragic heroes of the play. Antigone is considered the tragic hero because of the characteristics she shows such as her ambition to defeat Creon, Creon shows more of the characteristics clearly. Creon is the king of Thebes. He is also Antigones uncle. Creon became king after a fight between Eteocles and Polyneices. One may see Creon as a harsh and controlling ruler, but he is not good nor bad because he shows signs of both like whenRead MoreComparing Oedipus The King And Antigone1311 Words   |  6 Pagesanalyzing both Oedipus the King and Antigone, Oedipus and Antigone are very alike in ways. When reading these plays, the mind is wired to compare how the protagonists are alike, and contrast how they are different. Antigone and Oedipus are idolized by the people, but the legacy of Oedipus seems to have been altered due to the fact that he has experienced bad past family relationships; therefore as Gale explains, †Å"Antigone hangs herself. Creon’s son Haemon, who was in love with Antigone, commits suicideRead More The Tragic Hero: Creon or Antigone? Essay1293 Words   |  6 Pagestragedy Antigone, the characters Antigone and Creon can both be thought of as the tragic hero of the play. Though Antigone does show some of these characteristics of a tragic hero, Creon demonstrates the attributes more clearly and concisely. Creon is the King of Thebes, as well as the uncle of Antigone. Creon took the throne after a tragic quarrel between his two nephews, Eteocles and Polyneices. Despite his harsh governing and his crude ideals, he is not good or bad. Creon is the tragic hero ofRead MoreAntigone - Paper 131697 Words   |  7 Pagesdrama was written in such a way that the characters are the pivotal aspect of the play. The main characters in Sophocles’ epic play, Antigone, are both very strong personalities, which naturally leads to conflict. Antigone and King Creon both have very inte nse beliefs and roles in this play that oppose each other, and although there is a family tie, will lead to an imminent tragedy. Antigone is a young women who believes in the loyalty of her family and fears no one and nothing. She is willing to giveRead MoreAntigone : A Complex, Yet Debatable Play1343 Words   |  6 PagesAntigone is a complex, yet debatable play, written by Sophocles somewhere around 442 BC (Johnston). Chronologically, it is the third of the three Theban plays, but was the first and also one of the most famous tragedies ever to be written (Sophocles). The setting of the play is set in front of the Palace, Thebes, and Ancient Greece, though most Greek playwrights were from Athens, their plays are hardly ever set there. (Sophocles). It begins with the death of two brothers, Polyneices and EteoclesRead More Creon As Tragic Hero of Sophocles’ Antigone Essay836 Words   |  4 PagesCreon As Tragic Hero of Sophocles’ Antigone Since the play’s inception, there has always existed a contention concerning the true hero of Sophocles’ Antigone. It is a widely held belief that Antigone must be the main character simply because she and the drama share name. This is, of course, a very logical assumption. Certainly Sophocles must have at least meant her to be viewed as the protagonist, else he would not have given her the play’s title. Analytically speaking, however, Creon doesRead MoreCreon as Tragic Hero1586 Words   |  7 PagesFinest In the Greek play Antigone, Creon and Antigone can both be claimed the title of Tragic Hero. Creon was made king when Oedipus Rex fled the kingship. Creon is the brother in law of Oedipus, and was giving the kingship only because Oedipus’s sons, Eteocles and Polyneices were killed trying to fight for the thrown. Antigone is Oedipus’s daughter and Creon’s niece. When it comes down to who the tragic hero is, Creon most definitely walks away with the title. A tragic hero by definition is ordinaryRead MoreAn Interpretive Analysis On Conflicting Self Reassurance1337 Words   |  6 Pages Antigone: An Interpretive Analysis on Conflicting Self-Reassurance Antigone is a complex, yet debatable play, written by Sophocles somewhere around 442 BC. Chronologically, it is the third of the three Theban plays, but was the first to be written. In addition, Antigone was also one of the most famous tragedies ever to be written. The setting of the play is set in front of the Palace, Thebes, and Ancient Greece. Though most Greek playwrights were from Athens, their plays areRead More Creon as Tragic Hero of Sophocles Antigone Essay593 Words   |  3 PagesCreon as Tragic Hero of Sophocles Antigone There has always been a bit of confusion as to the tragic hero of the Greek Drama Antigone. Many assume that simply because the play is named for Antigone, that she is the tragic hero. However, evidence supports that Creon, and not Antigone, is the tragic hero of the play. Examining the factors that create a Greek Tragedy, and a tragic character, it is clear that the tragic hero is in fact Creon. First, take into account the timeframe in which

British Airways - 3360 Words

Report on â€Å"British Airways Strategy Information Systems† TABLE OF CONTENTS CHAPTER 1: MISSION STATEMENT 3 CHAPTER 2: GOALS AND OBJECTIVES 4 CHAPTER 3: ENVIRONMENTAL ANALYSIS 5 PEST ANALYSIS 5 SWOT ANALYSIS 7 CHAPTER 4: INFORMATIONS SYSTEMS 8 INFORMATION SYSTEMS AT OPERATIONAL LEVEL 8 INFORMATION SYSTEMS AT MANAGERIAL LEVEL 11 INFORMATION SYSTEMS AT STRATEGIC LEVEL 13 CHAPTER 5: SUGGESTED STRATEGY 14 REFERENCES AND BIBLIOGRAPHY 15 Mission Statement: â€Å"To be the most exclusive and first choice airline for all airline travelers† We recommend a new mission statement after a consultation process involving our group members. The mission statement can replace an†¦show more content†¦Relevant key performance indicators (KPI) are set. Environmental Analysis: Economic Increased interest rates credit crunch in US are affecting people to spend on luxuries like long distance air travel. The economic environment of the airline sector has been characterized by growth in relation to most key figures. Air travel demand has closely mirrored the cyclical pattern shown by gross domestic product (GDP) figures in that it responds to cyclical upswings and downswings. However, air travel growth has far exceeded GDP growth over the period. Between 1960 and 1995 the total world economy, measured by GDP, grew by a factor of just over three, while air transport, measured by tonne-kilometres, grew by a factor of nearly 20 (Hanlon, 1999).Furthermore, fuel and aircraft prices are major expenditure items subject to fluctuations and the international orientation of the industry means that movements in foreign exchange rates can have major effects upon industry profitability. Holloway (1998) maintained that aviation managers face the need to pursue strategies capable of sustaining profitability throughout entire economic cycles. Social Increased popularity in foreign travel is leading to a boom in demand for air travel. However, this has been adversely affected by international terrorism. A number of demographic factors point towards a greater use of air travel. Thus an increasing proportion of the population is relatively healthy and prosperous, increasingShow MoreRelatedBritish Airways3107 Words   |  13 PagesINTRODUCTION This report will be based upon a promotional plan for revenue enhancement, consisting of a marketing audit of British Airways (BA). It is essential to gather and explore most recent published company information, in order to examine the overall marketing performance of the company. This would further permit a detailed and applicable marketing review of British Airways marketing performance for a given period of time, in relation to internal examination covering a Marketing Mix of theirRead MoreBritish Airways6908 Words   |  28 PagesBRITISH AIRWAYS Introduction: The world today has evolved in numerous ways thanks to the many inventions and discoveries, but few have changed the way people live and experience the world as deeply as the invention of the airplane. The industry has progressed to the point where now it would be impossible to think of life without air travelling (for developed countries). Thanks to this, long distances have been somehow ‘shortened hence altering peoples concept of distance. As well, making itRead More Analysis of British Airways3333 Words   |  14 PagesTABLE OF CONTENTS PAGE 1. British Airways: Overview 4 2. Key stakeholders 4 3. Mission and objectives 5 4. Market structure 6 5. Managing diverse cultures 7 6. Economic changes, fiscal and monetary policy 8 7. Regulation 11 8. Conclusion and Recommendations 12 9. References 14 Executive Summary British Airways has focused its mission and objectives towards satisfying its key stakeholders that include employees, customers, Government and the British public. The company has beenRead MoreHistory of British Airways3844 Words   |  16 PagesHistory: British Airways PLC is the largest international airline in the world. It is based at Heathrow Airport in London, the busiest international airport in the world, and has a global flight network through such partners as USAir in the United States, Qantas in Australia, and TAT European Airlines in France. Via its own operations and those of its alliance partners, British Airways serves 95 million passengers a year using 441 airports in 86 countries and more than 1,000 planes. British AirwaysRead MoreBritish Airways Valuation8265 Words   |  34 Pagesgovernment increases the interest rate to avoid inflation during past years. HM-Treasury in November 2003 forecasted the economy to grow by 2.6% form 2004 to 2005 and slow down marginally to 2.4% from 2006 to 2007. Section 1 Company Profile British Airways Plc (BA). The Group s principal activities are the operation of international and domestic scheduled and charter air services for the carriage of passengers, freight and mail and the provision of ancillary services. The Group s global allianceRead MoreBritish Airways Analysis2158 Words   |  9 Pagessupplier of British airways, as a stakeholder it plays an important role in the development of the firm whereas it is also crucial to assess the stakeholder for maintaining the long-term relationships. There are three main connection features, which drives the value of the stakeholders. This essay will map British Airways stakeholders as well as the ethical concerns it has dealt with from its different stakeholders Background of British Airways The group of British airways comprises of British airwaysRead MoreThe Purpose of British Airways Essay790 Words   |  4 Pageswww.flyertalk.com www.britishairways.com L01: Understanding the organisational purposes of business Task 1 1.1a: The British Airways background: British Airways came into existence since civil aviation began shortly after World War I. A lot has changed in the 90 years from the worlds first schedule air service on 25 August 1919 to the present day civil air travel. Every 10 years since civil aviation began. The world has seen changes in the types of planes that have been in service toRead MoreBritish Airways Management Analysis6222 Words   |  25 PagesManagement Research Report What has British Airways done during the recession to be competitive against Ryanair and Easyjet? Table of Contents 1. Introduction †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 3 2. Methodology †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. 4 3. Short History 3.1 British Airways †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦5 3.2 Easyjet and Ryanair†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..6 4. Prior to the Recession 4.1 British Airways †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Read MoreBritish Airways - Organizational Structure5689 Words   |  23 Pages2009 Structural Perspective: British Airways Andrà © Costa Choi Sin Man Jiyun Baek 0 1 – Introduction In different working fields, companies face the pressure of globalization, and they must find new ways to overcome this challenge. The following example, introduces the case of British Airways, which needs to deal with the globalization issue trying to reduce the operational costs, increase profits and provide suitable services to customers. According to British Airways annual report from 2008/2009Read MoreBritish Airways Case Study3091 Words   |  13 PagesIntroduction British Airways is the one of the largest airline companies, and the passengers carry overall in the fifth largest in the world. Most of plans are stay in Heathrow Airport which is the highest of main international airport. The British Airways has a long history and airlines cover 133 countries; include 373 airplanes. The BA Company includes 50,086 workers to be in the service, which is one of the largest employers and employees in the United Kingdom. British Airways (BA) is based

Eggshell Membrane Reduces Joint Pain free essay sample

All rights reserved. no part of this book may be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording, or by an information storage and retrieval system, without written permission from the publisher. in other words, don’t copy any of our work, sell it for profit, or pass it off as your own. That would be wrong. But you already knew that. however, there is something we would like you to do: Read this book and share it. We want everyone to read and benefit from this book, which is why it’s free. if you like it and think your friends, family, colleagues, customers, subscribers, or neighbours would find value in it, spread the word. This book is free. Print it, share it, link to it, quote it—all we require is that you give us credit by letting people know we’re the authors when you do. a link back to the book or to precisionnutrition. com would be appreciated too. Design Carmelo Galati, SeeSaw Creative Communications, [emailprotected] ca Published Precision nutrition inc. , precisionnutrition. com aBSTRaCT Can Eggshell Membrane Reduce Joint Pain? BaCkGRound While many conventional treatments have been used to remedy chronic joint pain, interest continues to grow in the area of alternative, natural treatments. Eggshell membrane (EM) supplementation is a novel treatment for joint health, and has recently been shown to rapidly and continually improve joint pain in patients with osteoarthritis and joint and connective tissue disorders. The current study aimed to observe the effects of one particular eggshell membrane product (fast joint care+; FJC+) supplementation on chronic joint pain in physically active adults. METhodS Sixty adults (40. 2  ± 10. 2 y; 78. 6  ± 10. 2 kg) experiencing chronic joint pain supplemented daily with either 500mg FJC+ or placebo, over the course of 4 weeks. Participants also completed a weekly exercise protocol designed to challenge their irritated joint. Participants then rated their joint pain immediately, and one day after, this exercise challenge. RESulTS Participants in the FJC+ group reported significantly less joint pain post-exercise following FJC+ supplementation (-16. 13  ± 3. 60) when compared to those in the placebo group (–4. 30  ± 2. 84; p=0. 00171). In addition, during the 4 week study, both groups experienced decreases in next day joint pain (p=0. 0015), although there were no significant differences between the two groups (pgt;0. 05). ConCluSionS In the current study, daily FJC+ supplementation appeared to decrease post-exercise joint pain vs. placebo, although this effect did not persist 24 hours post-exercise. Because eggshell membrane research is in its infancy, further research may be needed to clarify its utility in managing joint pain. 1 Precision Nutrition | www. precisionnutrition. com BaCkGRound Why Study Eggshell Membrane? n the united States, over 20% of adults have reported doctor-diagnosed joint and connective tissue (JCT) disorders; this number has been projected to increase by 40% over the next 25 years [1, 2]. numerous forms of intervention have been used as treatments to improve joint pain. Conventionally, nonsteroidal antiinflammatory drugs (nSaids) and analgesics have been used to address joint pain associat ed with JCT disorders; however, their long term use has been associated with diverse and severe side effects including cardiac and gastrointestinal complications [3, 4]. Alternative therapies used to treat joint pain include dietary supplements; the most popular of these supplements being glucosamine, chondroitin and methylsulfonylmethane (MSM). While many turn to these complementary treatments to avoid the side effects associated with NSAIDs and analgesics, there is little evidence to support their effectiveness, and the evidence that does exist is equivocal [5]. Several large-scale human clinical trials [6], including the National Institutes of Health-sponsored Glucosamine/Chondroitin Arthritis Intervention Trial, as well as a few additional meta-analyses and reviews [5, 7] have reported limited effectiveness of glucosamine and chondroitin supplementation in reducing joint pain. However, other groups have noted long-term improvements in joint pain from glucosamine supplementation alone [8], and further enhanced effectiveness of combined glucosamine sulfate and chondroitin sulfate, rather than the separate use of either supplement [5, 9]. The question of their effectiveness in JCT populations is subject to ongoing debate. There has been growing interest in eggshell membrane (EM) supplementation as a treatment for joint pain, as it does not present the side effects of conventional treatments (NSAIDs). Eggshells and their membranes have been extensively analyzed 2 Eggshell Membrane Reduces Joint Pain for their components: the separate layers of the eggshell have been analyzed and found to contain several types of collagen (types X, I, V) [10-12]. Additionally, EM has been found to have notably high concentrations of a number of amino acids [13], collagenlike proteins [14-16], enzymes [17-19] and glycosminoglycans (GAGs). Glycosaminoglycans are of high interest, as they play key roles in connective tissue [20]. Glucosamine, hyaluronic acid and chondritin sulfate are important GAGs in EM (21, 22). With the high protein and enzyme content, and naturally occurring GAGs in EM, scientists and nutritional supplement companies have speculated that it could present a viable alternative to traditional joint disorder and osteoarthritis treatments. Additionally, while the aforementioned elements of EM have been detected, it should be noted that membrane components have not yet been wholly characterized; there are likely a number of compounds that have yet to be identified in the membrane. Some of these yet undetected elements may contribute to benefits or improvements seen in joint health. To date, very few studies have investigated the effects of EM supplementation on joint pain and range of motion. In rats, 4 weeks of EM treatment led to significant reductions in many proinflammatory cytokines (measured in plasma), notably including TNF-? nd IL-1 [23]. Two recent clinical reports [24, 25] investigated the timing and effectiveness of EM supplementation in JCT and osteoarthritis patients experiencing severe pain and limited range of motion. These patients received daily 500mg doses of oral EM for four to eight weeks. Rapid (seven to ten days) and continuous effects were seen in terms of reduced pain and stiffness, as well as im proved flexibility. In both investigations, there were no reports of adverse effects with supplementation. In the present study, we set out to observe the effects of EM (fast joint care+; FJC+) supplementation on joint pain within a physically active adult population experiencing chronic joint pain in one of four joints (ankle, knee, shoulder or elbow). As many adults use exercise to manage joint and connective tissue disorders, this population would likely see great benefit from adjunct therapies designed to reduce pain and increase range of motion. 3 Precision Nutrition | www. precisionnutrition. com METhodS What We Did. And How We Did It. Prior to commencing the study, all participants gave their informed consent. A total of 60 adults between the ages of 18 and 70 (45 men and 15 women; 40. 2  ± 10. 2 y; 78. 6  ± 10. 2 kg; see Table 1) agreed to participate. Each reported chronic pain in one of the following joints: elbow, shoulder, ankle or knee. Participants were recruited online through a popular health and fitness community and data were collected through self reports in a distance-based capacity. Participants were also prescreened to exclude those who had used any additional medications (methotrexate or immunosuppressants), NSAIDs, analgesics, or joint supplements (MSM, glucosamine or chondroitin) two weeks prior to the start of the study. Those with egg allergies, or who were pregnant or breastfeeding, were also excluded. Participants were asked to refrain from use of pain medications throughout the study period. TaBlE 1. dEMoGRaPhiCS of BoTh SuPPlEMEnT and PlaCEBo GRouPS GRouP MalES fEMalES aGE (yRS) WEiGhT (kG) knEE loCaTion of Join Pain ShouldER ElBoW anklE Supplement Placebo 23 22 7 8 41. 0 +/- 10. 0 39. 4 +/- 10. 5 78. 6 +/- 10. 4 78. 6 +/- 10. 1 12 13 10 10 6 5 2 2 Sex, age, weight, and reported joint pain area are shown for each group. In order to participate, individuals had to be exercising regularly, at least three times per week. They were screened for their regular physical activity (reported 4. 8  ± 1. 1 exercise sessions/wk), and asked to ensure that both their exercise and nutritional regimens remained unchanged over the course of the study. After matching for age, sex, and affected joint, participants (n=60) were randomly assigned to receive either the EM supplement (fast joint care+; FJC+), or a placebo supplement for 4 weeks. These groups did not differ significantly in terms of age or weight, contained similar numbers of men and women, and contained similar numbers of individuals with shoulder, elbow, knee, and ankle pain (see Table 1). All supplements were provided to subjects in identically marked containers, and all capsules (placebo and FJC+) were identical in appearance (color, flavor, size). All participants were instructed to take their â€Å"supplement† once per day, at the same time of day (i. e. first thing in the morning, with breakfast). 4 Eggshell Membrane Reduces Joint Pain Each capsule of the FJC+ supplement contained 500mg of Gallus gallus (chicken) eggshell membrane extract (a commercial preparation sold as fast joint care+ by Genuine Health, Toronto, Ontario); additional non-medical ingredients included rice flour, magnesium stearate, gelatin, and water. The color and flavor matched placebo capsules contained only rice flour, magnesium stearate, gelatin, and water. The individual components of FJC+ were not quantified in the supplement as the product is intended to be used as a complete eggshell membrane extract, without additional ingredients (ie. additional glucosamine, chondroitin, etc. . In addition to their normal exercise program, participants were asked to complete an additional exercise challenge once per week. This exercise challenge was to be completed on the same day of each week (Monday) and at the same time of day (in the morning, after supplementation and breakfast). The exercise challenge for those with chronic shoulder or elbow pain consisted of pushups. For those with chronic knee or ankle pain, the exercise challenge consisted of jump squats. Each of these sessions involved performing 10 sets of 5 repetitions of the given movement, with 2 minutes of rest between sets. Immediately after each exercise challenge session, participants rated their specific joint pain on a Visual Analog Scale (VAS) at two time points: within 10 minutes of completing the challenge and 24 hours following the challenge. Compliance to the exercise programming and supplementation schedule was self-reported and logged by participants; those logs were provided to researchers weekly via email. Subjects were also asked to report any side effects during the trial. Joint pain was assessed using a 100mm visual analog scale (VAS), and participants submitted this information via electronic form. A self-assessment was performed at the two time points (post-exercise, and next day after exercise) for each of the 4 weeks. Each subject was asked to â€Å"click on the line below to indicate how severe the pain is on the affected joint with 0 being no pain and 100 being pain as bad as it can be†. Responses were submitted electronically on a weekly basis, after each pair of assessments. VAS scores were then measured in millimeters from the left hand end of the scale to the point marked by the subject. Data were collected across the 4 weeks of supplementation, and analyzed using a two-way ANOVA with repeated measures (i. . MANOVA). In cases of significant interactions (p? 0. 05) post-hoc analysis was performed using Student’s t-test for comparison between groups, and paired t-test for comparison within groups (JMP, SAS Institute Inc. , Cary, NC). The VAS ratings were reported on a scale of 0 to 100, with 0 indicating no pain, and 100 representing greatest pain. Where ap propriate, change scores were examined after adjusting absolute scores and then comparing between groups with a one-way analysis. All values are reported as mean  ± SEM, and statistical significance was set at p? 0. 5. To summarize the protocol in brief: During week 1 of the investigation, subjects took their first 500mg dose of FJC+ with breakfast on Monday. After breakfast they immediately performed their first exercise challenge and then rated their joint pain using the VAS described above. In addition, they rated their joint pain on Tuesday, 24h later. During each subsequent week, subjects repeated the same protocol, providing 4 weeks’ worth of joint pain data, with week 1 serving as a baseline. 5 Precision Nutrition | www. precisionnutrition. com RESulTS So What Happened? Following 4 weeks of supplementation, participants in the FJC+ group had a significantly greater decrease in post-exercise joint pain compared to participants in the placebo group (-16. 13  ± 3. 60 in the FJC+ group and –4. 30  ± 2. 84 in the placebo group; p=0. 0171; see Figure 1). Figure 2 illustrates changes in joint pain between groups across the 4 weeks of supplementation: main effects were found for both time (p=0. 0003) and the interaction between group and time (p=0. 0354). 0 Change in Joint Pain Index (VAS) -5 Placebo FJC+ -10 -15 -20 * -25 Figure 1. Mean change in joint pain (measured with VAS) following 4 weeks of supplementation. Participants in the FJC+ group experienced significantly larger decreases in post-exercise joint pain compared to participants in placebo group (p=0. 0171). Note: absolute scores were adjusted into change scores, which were then compared between groups using a one-way analysis. 6 Eggshell Membrane Reduces Joint Pain 50 Joint Pain Index (VAS) 40 30 20 10 0 1 2 Weeks 3 4 FJC+ Placebo * Figure 2. Post-exercise joint pain (measured with VAS) across 4 weeks of supplementation. There was a main effect for time (p=0. 0003), and an interaction between time and group (p=0. 354), indicating greater joint pain decreases in the FJC+ group (-43. 4%) than the placebo group (-30. 6%). Post-hoc analysis showed between group differences from week 1 to week 4 (p=0. 0171). Note: higher VAS values indicate more pain. In accordance with Figure 1, post-exercise joint pain in the FJC+ group decreased by 43. 4% while the placebo group experienced a 30. 6% decrease in pain over the 4 week period. Post-hoc analysis shows a mean difference between groups when comparing overall change in pain from week 1 to week 4 (p=0. 0171). Next day reports of joint pain also decreased over time (p=0. 015; see Figure 3) with next day joint pain decreasing by 46. 7% in the FJC+ group (from 35. 34  ± 4. 33 during week 1 to 18. 82  ± 4. 38 during week 4) and by 40. 9% in the placebo group (from 26. 38  ± 4. 58 during week 1 to 15. 59  ± 4. 01 during week 4). There were no significant differences between the groups’ joint pain scores across the 4 weeks of supplementation (p=0. 1971 for group and time interaction). 7 Precision Nutrition | www. precisionnutrition. com 50 Joint Pain Index (VAS) 40 30 20 10 0 1 2 Weeks 3 4 FJC+ Placebo Figure 3. Next day joint pain (m easured with VAS) across 4 weeks of supplementation. A main effect was seen for time (p=0. 0015). However, there were no significant differences between groups across the 4 weeks (pgt;0. 05), indicating similar joint pain decreases in both the FJC+ group (-46. 7%) and the placebo group (-40. 9%). Note: higher VAS values indicate more pain. Participants in both placebo and FJC+ supplementation groups did not report any side effects during the study. 8 Eggshell Membrane Reduces Joint Pain diSCuSSion Some Clarifications About Our Work The results of this investigation suggest that four weeks of supplementation with 500mg fJC+ daily improves post-exercise joint pain vs. upplementation with placebo, specifically in physically active adults experiencing pain in the ankles, knees, shoulders, and elbows. Other investigations using EM supplementation have observed similar reductions in joint pain, specifically in populations with osteoarthritis and JCT disorders. In one randomized, double-blind, placebo-controlled study, daily oral administrati on of either 500mg placebo or 500mg EM was given to patients with knee osteoarthritis [24]. After 10 days, rapid improvements in both joint pain and stiffness were seen in the EM group. Improvements in pain and stiffness were sustained (and enhanced) following 60 days of administration. A similar study with JCT patients [25] also observed both rapid (7 days) and sustained (30 days) improvements in pain and flexibility following daily administration of 500mg EM. There were no adverse events reported in either study, and the treatments appeared to be well tolerated by the patients. These statistically and clinically significant outcomes suggest that EM supplementation may be a natural and effective alternative therapy for both clinical populations with limited activity levels as well as physically active populations. Many of the various components present in EM have been thoroughly analyzed. Eggshells consist of a number of layers: an inner and outer membrane, a mammillary layer (connecting the eggshell and outer membrane), an outer palisade layer, and an outer cuticle covering the eggshell [10]. The inner and outer shell membranes are the first layers of extracellular matrix covering the egg itself [11]; the outer membrane is predominantly made of type I collagen, whereas the inner membrane consists mainly of type V collagen [12]. In addition, type X collagen has been reported to occur in both of these membrane structures [10]. EM amino acid profiles have also shown high concentrations of arginine, glutamic acid, histidine, cystine and proline [13]. Additionally, a number of collagen-like proteins (including hydroxyproline, hydroxylysine, desmosine, and isodesmosine) are primary structural components of the membranes. 9 Precision Nutrition | www. precisionnutrition. com Other components have been quantified in EM including: lysyl oxidase (reported to play a role in the development and repair of connective tissue), ovotransferrin, and lysozyme [17-19]. However, the presence of glycosaminoglycans in EM is of particular interest. Glycosaminoglycans (GAGs), such as glucosamine, are composed of repeating hexosamine disasccharides and act as major components of connective tissue [20]. Clearly, there are a number of individual components present in the EM that have known physiological roles in joint and connective tissue; however, EM is novel in that it is a natural extract that provides a combined source of these compounds. The absolute quantity of each component in the EM is not known, and those quantities may likely vary with each extraction in the supplement production process. Additionally, it is plausible that a number of yet unisolated elements, proteins, and enzymes exist in EM, which may also contribute to improved joint and connective tissue health. Therefore, the observed benefits associated with EM supplementation may not be directly attributable to any one specific component of the supplement (ie. lucosamine, chondroitin, etc. ); it may be more appropriate to assume that the combined effects of the known—and unknown—components of EM contribute to the observed improvements in joint health. A number of individual components in EM are known to have important roles in maintaining connective tissue in vivo, though the physiological mechanisms by which those components improve overall joint health through supplementation (flexibility, connective tissue repair and maintenance) have no t been measured in humans. One experiment, however, investigated the effects of EM supplementation on systemic pro- and anti-inflammatory markers in rats [23]. In this study, rats were given oral doses of EM for 7 days. Significant decreases were observed in plasma levels of numerous inflammatory antigens following supplementation; thus, it is possible that the anti-inflammatory effects of oral EM supplements may contribute to the improvements in joint pain ratings seen in human trials. More research is warranted to investigate these effects. Interestingly, the most pronounced effects of FJC+ supplementation in this study were present in post-exercise ratings of joint pain. This may be due to the proposed anti-inflammatory benefits associated with EM. If the exercise challenge used in this investigation led to acute joint inflammation, it stands to reason that the most pronounced impact of EM would be to reduce the pain associated with this postexercise increase in inflammation.